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Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

Authors:	Joungmok Kim Young Chul Kim Chong Fang Ryan C Russell Jeong Hee Kim Weiliang Fan Rong Liu Qing Zhong Kun-Liang Guan

Institution:	1. Department of Oral Biochemistry and Molecular Biology, Research Center for Tooth and Periodontal Tissue Regeneration, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea;2. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92130, USA;3. Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA

Abstract:	Download : Download high-res image (245KB) Download : Download full-size image Highlights? Different Vps34 complexes are distinctly regulated upon energy stress ? AMPK activates the proautophagy Vps34 complex by phosphorylating Beclin1 ? AMPK inhibits the nonautophagic Vps34 complex by phosphorylating Vps34 ? ATG14L determines whether the Vps34 complex is activated or inhibited by AMPK

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