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Folding and Self-Assembly of the TatA Translocation Pore Based on a Charge Zipper Mechanism

Authors:	Torsten H Walther Christina Gottselig Stephan L Grage Moritz Wolf Attilio V Vargiu Marco J Klein Stefanie Vollmer Sebastian Prock Mareike Hartmann Sergiy Afonin Eva Stockwald Hartmut Heinzmann Olga V Nolandt Wolfgang Wenzel Paolo Ruggerone Anne S Ulrich

Institution:	1. Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), Institute of Organic Chemistry and CFN, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany;2. KIT, Institute of Nanotechnology and CFN, POB 3640, 76021 Karlsruhe, Germany;3. Istituto Officina dei Materiali/CNR UOS SLACS and Dipartimento di Fisica, Università di Cagliari, S.P. Monserrato-Sestu Km 0.700, 09042 Monserrato (CA), Italy

Abstract:	Download : Download high-res image (202KB) Download : Download full-size image Highlights? Charge zippers as a new concept for folding and assembly of membrane proteins ? 3D structure of TatA pore explains translocation of folded proteins across membrane ? Ladders of salt bridges connect an amphiphilic palisade that can span the bilayer ? MD simulations and specific charge mutations support the charge zipper model

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