1. Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;2. Department of Radiology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;3. Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany;5. Beatson Institute for Cancer Research, Glasgow G61 1BD, UK;6. Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, 1105 BK Amsterdam, Netherlands;7. Department of Dermatology and Allergology, Ludwig-Maximilians-University, 80337 Munich, Germany;8. Institute of Pathology, Ludwig-Maximilians-University, 80337 Munich, Germany;9. Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, Singapore 138648, Singapore;10. Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, 3584CT Utrecht, Netherlands;11. Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, 91054 Erlangen, Germany;12. Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan
Abstract:
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Highlights? Epithelial nonstem cells can be reprogrammed into tumor-initiating cells ? Dedifferentiation depends on degree of Wnt signaling ? Wnt signaling is enhanced by NFkB via the coactivator CBP ? Differentiation of stem cells into nonstem cells is bidirectional
