Latent Enhancers Activated by Stimulation in Differentiated Cells |
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| Authors: | Renato Ostuni Viviana Piccolo Iros Barozzi Sara Polletti Alberto Termanini Silvia Bonifacio Alessia Curina Elena Prosperini Serena Ghisletti Gioacchino Natoli |
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| Affiliation: | 1. Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy |
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| Abstract: |  Download : Download high-res image (220KB)Download : Download full-size imageHighlights? Latent enhancers are regulatory elements unmarked and unbound in differentiated cells ? Stimulus-dependent TFs co-opt lineage-determining TFs to activate latent enhancers ? Latent enhancers may confer short-term memory of environmental exposure ? Environmental stimulation qualitatively alters the pre-existing enhancer repertoire |
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