Design and synthesis of novel D-ring fused steroidal heterocycles |
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Authors: | Bao-Le Zhang En Zhang Lu-Ping Pang Li-Xing Song Ya-Fei Li Bin Yu Hong-Min Liu |
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Institution: | School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China |
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Abstract: | Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo 2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yields of these products are moderate to good and the reaction conditions are mild. The cytotoxicity of the synthesized compounds against EC-109(human esophageal carcinoma), EC-9706(human esophageal carcinoma), MGC-803(human gastric carcinoma) were investigated. |
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Keywords: | Dehydroepiandrosterone Imidazo [2 1-b]thiazole Imine |
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