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Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State
Authors:Michael A Cianfrocco  George A Kassavetis  Patricia Grob  Jie Fang  Tamar Juven-Gershon  James T Kadonaga  Eva Nogales
Institution:1. Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA;2. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA;3. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA;4. Division of Biological Sciences, Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA;5. Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel;6. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Abstract:
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  • Highlights? TFIID has distinct conformations with different positions of the TBP-containing lobe ? A rearranged state of TFIID interacts with promoter DNA in a TFIIA-dependent manner ? TFIID induces multiple topological changes on promoter DNA around the start site ? The different conformations of TFIID may serve as targets for regulatory factors
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