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The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster
Authors:Sonja?J.?Prohaska,Claudia?Fried,Chris?T.?Amemiya,Frank?H.?Ruddle,Günter?P.?Wagner,Peter?F.?Stadler  author-information"  >  author-information__contact u-icon-before"  >  mailto:peter.stadler@bioinf.uni-leipzig.de"   title="  peter.stadler@bioinf.uni-leipzig.de"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstraßse 7b, D-04103 Leipzig, Germany;(2) Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universität Wien, Währingerstraße 17, A-1090 Wien, Austria;(3) Molecular Genetics Department, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA;(4) Department of Cellular and Developmental Biology, Yale University, New Haven, CT 08540, USA;(5) Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 08540, USA;(6) The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
Abstract:The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.
Keywords:Hox clusters  Phylogenetic footprints
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