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Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma |
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| Authors: | Sudjit Luanpitpong Jirarat Poohadsuan Parinya Samart Chayanin Kiratipaiboon Yon Rojanasakul Surapol Issaragrisil |
| Affiliation: | 1. Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;2. Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;3. WVU Cancer Institute and Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA;4. Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;5. Bangkok Hematology Center, Wattanosoth Hospital, BDMS Center of Excellence for Cancer, Bangkok, Thailand |
| Abstract: | |
| Keywords: | ALDH aldehyde dehydrogenase ALL acute lymphocytic leukemia AML acute myeloid leukemia CLL chronic lymphocytic leukemia CML chronic myelogeneous leukemia CSC cancer stem cells DEAB diethylaminobenzaldehyde DHE dihydroethidium DMNQ 2,3-dimethoxy-1,4-naphthoquinone 4 ferrous sulfate 2 2′,7′-dichlrofluorescin diacetate 2 hydrogen peroxide HPF 3′-p-(hydroxylphenyl) fluorescein HSC hematopoietic stem cells MCL mantle cell lymphoma MnTBAP Mn (III) tetrakis (4-benzoic acid)-porphyrin chloride NaFM sodium formate NHL non-Hodgkin lymphoma 2 superoxide hydroxyl radical ROS reactive oxygen species Reactive oxygen species Cancer stem cells Bortezomib Zeb-1 Mcl-1 Mantle cell lymphoma |
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