Guiding ligands to nuclear receptors |
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| Authors: | Michalik Liliane Wahli Walter |
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| Institution: | Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland. |
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| Abstract: | Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively. |
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