LPS/TLR4 signal transduction pathway |
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| Authors: | Lu Yong-Chen Yeh Wen-Chen Ohashi Pamela S |
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| Affiliation: | The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9. |
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| Abstract: | The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway. |
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