Perfluoroarylazide derivatives of 2'-O-modified oligoribonucleotides: efficient reagents for RNA photomodification |
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| Authors: | Novopashina D S Kulikov R N Kuznetsova M A Venyaminova A G Zenkova M A Vlassov V V |
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| Affiliation: | Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. |
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| Abstract: | Site-specific photomodification of the 5'-terminal fragment of MDR1 mRNA by perfluoroarylazide derivatives of 2'-O-modified (2'-O-methyl or 2'-O-tetrahydropyranyl) oligoribo- and oligodeoxyribonucleotides was investigated. The conjugates built of 2'-O-modified oligoribonucleotides demonstrate beneficial features compared with their deoxyribo analogs: the extent of RNA modification by 2'-O-modified oligoribonucleotides and oligodeoxyribonucleotide conjugates was 40- 50% and 20%, respectively. |
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