| 适用于MR成像的多发性硬化大鼠模型的研究进展 |
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| 引用本文： | 张海琴,李坤成,盛树力.适用于MR成像的多发性硬化大鼠模型的研究进展[J].中国实验动物学报,2010,18(5):433-436. |
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| 作者姓名： | 张海琴 李坤成 盛树力 |
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| 作者单位： | 1. 首都医科大学宣武医院影像部放射科,北京,100053
2. 首都医科大学宣武医院中心实验室,北京,100053 |
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| 基金项目： | 北京市自然科学基金，中外医学磁共振交流基金 |
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| 摘 要： | 多发性硬化(MS)是中青年非外伤性致残的最常见原因,但是MS的发病机制迄今尚不完全明了。核磁共振成像(MRI)是目前诊断、监测MS的重要手段。实验性自身免疫性脑脊髓炎(EAE)是公认的研究人类MS的动物模型,MRI为EAE模型的评估提供直接、客观的影像学依据。理想的EAE大鼠模型不仅有助于开展对MS的防治、发病机理、相关药物开发等多方面的研究,而且为MRI提供合适的研究平台,对MS早期诊断、病情的监测和评价提供重要线索。
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| 关 键 词： | 多发性硬化 实验性自身免疫性脑脊髓炎 髓鞘少突胶质细胞糖蛋白 磁共振成像 |
Progress in Research of Rat Models of Experimental Autoimmune Encephalomyelitis Suitable for MR Imaging |
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| ZHANG Hai-qin,LI Kun-cheng,SHENG Shu-li.Progress in Research of Rat Models of Experimental Autoimmune Encephalomyelitis Suitable for MR Imaging[J].Acta Laboratorium Animalis Scientia Sinica,2010,18(5):433-436. |
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| Authors: | ZHANG Hai-qin LI Kun-cheng SHENG Shu-li |
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| Institution: | 1.Department of Medical Imaging,Xuanwu Hospital,2.Central Lab of Medical Imaging,Capital University of Medical Sciences,Beijing 100053,China) |
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| Abstract: | The most common cause of non-traumatic disability in adults is multiple sclerosis （MS）.However,the pathomechanisms of MS have not been fully clarified yet.Magnetic resonance imaging （MRI） is an important tool for monitoring the development of lesions and assessing the efficacy of treatments in MS in vivo.Experimental autoimmune encephalomyelitis （EAE） is an available animal model for studying MS.MRI provides direct and objective basis for the assessment of EAE models.An appropriate animal model can be applied in research of prevention and treatment,etiology and mechanism,new medicines and therapeutic strategies of MS,and also to provide an opportunity for MR research in early diagnosis and assessment of multiple sclerosis. |
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| Keywords: | Multiple sclerosis Experimental autoimmune encephalomyelitis Myelin oligodendrocyte glycoprotein Magnetic resonance imaging |
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