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8-Methoxyquinolines as PDE4 inhibitors |
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| Authors: | Billah Motasim Buckley George M Cooper Nicola Dyke Hazel J Egan Robert Ganguly Ashit Gowers Lewis Haughan Alan F Kendall Hannah J Lowe Christopher Minnicozzi Michael Montana John G Oxford Janet Peake Joanna C Picken C Louise Piwinski John J Naylor Robert Sabin Verity Shih Neng-Yang Warneck Julie B H |
| Institution: | Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA. |
| Abstract: | The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4). |
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