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Glucose and ketone bodies production in hepatocytes isolated from fetuses at term--II. Effect of maternal adrenalectomy |
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| Authors: | R M Arahuetes J López M Ramos |
| Affiliation: | 1. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA;2. Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, CA 90095, USA;3. Department of Chemical and Biomolecular Engineering, UCLA, Los Angeles, CA 90095, USA;4. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA;5. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA;6. Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA;7. Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan |
| Abstract: | Glucose and ketone bodies production has been studied in hepatocytes isolated from fetuses at term of fed and fasted adrenalectomized mothers. Maternal adrenalectomy diminishes the fetal liver weight. This effect is increased when the adrenalectomized pregnant rat is fasted for the last 2 days of gestation. Maternal adrenalectomy diminishes glucose production in hepatocytes isolated from fetuses at term. This diminution is markedly greater when the adrenalectomized pregnant rat is fasted for the last 48 hr of gestation. Maternal adrenalectomy diminishes ketone bodies production in hepatocytes isolated from fetuses at term. |
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