Notch around the clock. |
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| Authors: | O Pourquié |
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| Institution: | Laboratoire de Génétique et de Physiologie du Développement (LGPD) CNRS-INSERM-Université de la Méditerranée - AP de Marseille Campus de Luminy, Case 907, 13288, Marseille,France. pourquie@ibdm.univ-mrs.fr |
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| Abstract: | The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems. |
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