首页 | 本学科首页   官方微博 | 高级检索  
   检索      


3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
Authors:Weide Timo  Arve Lars  Prinz Heino  Waldmann Herbert  Kessler Horst
Institution:1. Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany;2. Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, D-44227 Dortmund, Germany;3. Abteilung für Chemische Biologie, Universität Dortmund, Otto-Hahn-Straße 6, D-44221 Dortmund, Germany;1. Department of Clinical and Experimental Biomedical Science ‘Mario Serio’, University of Florence, Viale Morgagni 50, 50134 Florence, Italy;2. Department of Chemistry ‘Ugo Schiff’, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy;3. Interdepartmental Center for Preclinical Development of Molecular Imaging (CISPIM), University of Florence, Viale Morgagni 85, 50134 Florence, Italy;4. Department of Clinical and Experimental Biomedical Science ‘Mario Serio’, University of Florence, Largo Brambilla 3, 50134 Florence, Italy;5. Azienda Ospedaliera Universitaria Careggi (AOUC), Largo Brambilla 3, 50134 Florence, Italy;1. Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany;2. Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany;3. Technical University of Denmark, Department of Chemistry, Kemitorvet 207, 2800 Kgs, Lyngby, Denmark;4. Department of Chemistry, Umeå University, 90187 Umeå, Sweden;1. Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, Cd. México, Mexico;2. Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, Cd. México, Mexico;1. ‘Alexandru Ioan Cuza’ University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania;2. Hautes Etudes d’Ingénieur (HEI), Groupe HEI-ISA-ISEN, UCLille, Laboratoire de Pharmacochimie, 13 rue de Toul, F-59046 Lille, France;3. Inserm U995, LIRIC, Université de Lille, CHRU de Lille, Faculté de médecine—Pôle recherche, Place Verdun, F-59045 Lille Cedex, France;4. Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif, Avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France;5. Faculté des Sciences Pharmaceutiques et Biologiques de Lille, 3 Rue du Pr Laguesse, B.P. 83, F-59006 Lille, France;1. Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, North Rhine-Westphalia 44227, Germany;2. Faculty of Chemistry and Chemical Biology, TU Dortmund, Dortmund, North Rhine-Westphalia 44227, Germany;3. Department of Systemic Cell Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, North Rhine-Westphalia 44227, Germany;4. Structural Biology Group, Max-Planck-Institute of Molecular Physiology, Dortmund, North Rhine-Westphalia 44227, Germany;5. Lead Discovery Center GmbH, Otto-Hahn-Straße 15, 44227 Dortmund, Germany;1. School of Physical and Electronic, Henan University, Kaifeng 475004, People’s Republic of China;2. College of Computer and Information Engineering, Henan University, Kaifeng 475004, People’s Republic of China
Abstract:In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号