Results of Intracecal Inoculation of Germfree and Conventional Guinea Pigs and Germfree Rats with Axenically Cultivated Entamoeba histolytica |
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| Authors: | BRUCE P. PHILLIPS LOUIS S. DIAMOND IDA LOUISE BARTGIS STEPHEN A. STUPPLER |
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| Affiliation: | Laboratory of Microbial Immunity and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 |
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| Abstract: | SYNOPSIS. Germfree and conventional guinea pigs and germfree rats were inoculated with large numbers of axenically cultivated Entamoeba histolytica. Amebic lesions were not found in any of the animals, and there was no indication that the ameba had established lumen infections in any instance. The axenic amebae appeared to have lost their pathogenicity. This loss was believed to depend, in part at least, upon the fact that they did not encyst and thus did not complete their life cycle in axenic culture. |
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| Keywords: | Entamoeba histolytica axenic cultivation pathogenicity infectivity germfree and conventional guinea pigs germfree rats |
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