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Molecular structure of the Japanese hepatitis C viral genome |
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| Authors: | Nobuyuki Kato Makoto Hijikata Mosanori Nakagawa Yuko Ootsuyama Kanae Muraiso Showgo Ohkoshi Kunitada Shimotohno |
| Affiliation: | Department of Biochemistry, Yokohama City University School of Medicine, Kanagawa, Japan. |
| Abstract: | The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et. al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524–9528)indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase. NTPase and RNA-dependent RNA polymerase |
| Keywords: | Non-A, non-B hepatitis RNA virus HCV-J Amino acid sequence. |
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