AAA+ proteins: have engine, will work |
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Authors: | Hanson Phyllis I Whiteheart Sidney W |
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Institution: | Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. phanson@cellbiology.wustl.edu |
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Abstract: | The AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction. |
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