Structure–antimicrobial activity of some natural isocoumarins and their analogues |
| |
Authors: | K. Ferrazzoli Devienne, M.S. Gon alves Raddi, R. Gomes Coelho,W. Vilegas |
| |
Affiliation: | Instituto de Química de Araraquara, Universidade Estadual Paulista-UNESP, Araraquara, S?o Paulo, Brazil. |
| |
Abstract: | Three naturally occurring isocoumarins (paepalantine, paepalantine 9-O-beta-D-glucopyranoside and paepalantine 9-O-beta-D-allopyranosyl(1 --> 6) glucopyranoside) and two semi-synthetic analogues, 9,10-acylated compound and 9-OH-10-methylated compound, structurally similar to paepalantine, were evaluated for antimicrobial activity using a spectrophotometric microdilution technique. The paepalantine was active against S. aureus, S. epidermidis, and E. faecalis while the other four compounds proved ineffective against all microorganisms tested at concentrations of 500 microg/ml. Variations in phenolic substitution at OH-9 and/or OH-10 in the paepalantine molecule resulted in compounds without antimicrobial activity. A combination of structural features, two phenolic groups as cathecolic system, forms an oxygenated system arrangement that may reflect the potentially antimicrobial properties of paepalantine. |
| |
Keywords: | Antimicrobial activity Natural isocoumarins of Eriocaulaceae family |
本文献已被 ScienceDirect 等数据库收录! |
|