Substance K, a novel tachykinin injected bilaterally into the ventral tegmental area of rats increases behavioral response |
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Authors: | Y Takano Y Takeda K Yamada H Kamiya |
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Institution: | 7. Department of Pharmacology, School of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-01, Japan |
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Abstract: | Novel tachykinins such as substance K and neuromedin K have been identified in the mammalian CNS. Bilateral injections of substance K and related peptides as well as of substance P into the dopamine cell body area of the ventral tegmental area caused dose-dependent increases in locomotor activity and rearing, in rats. As this behavior was blocked by the pretreatment with haloperidol (0.1 mg/kg, i.p.), the activation of dopaminergic systems may be involved in the hypermotility induced by the administration of substance K. |
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