Longitudinal study of HTLV-III-infected chimpanzees by lymphocyte subpopulation analysis |
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Authors: | J W Eichberg H J Alter G R Dreesman |
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Abstract: | Following inoculation with plasma from human patients with AIDS, two chimpanzees demonstrated specific antihuman T-cell leukemia virus type 3 (HTLV-III) antibodies. One of the two chimpanzees also developed massive lymphadenopathy that persisted for 32 weeks and demonstrated a concurrent and more frequent depression of total T cells (T3) and T helper cells (T4) with a decrease in the ratios of T4 to T suppressor cells (T8). These results indicate that chimpanzees demonstrate a range of T-cell subpopulations during infection and disease induced by HTLV-III. |
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Keywords: | Acquired immunodeficiency syndrome HTLV-III Chimpanzee Immunology Lymphocyte subpopulations |
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