Defining an epigenetic code |
| |
Authors: | Turner Bryan M |
| |
Institution: | Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk |
| |
Abstract: | The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|