Mechanical and biological performances of new scaffolds made of collagen hydrogels and fibroin microfibers for vascular tissue engineering |
| |
Authors: | Mariana Agostini de Moraes Estelle Paternotte Diego Mantovani Marisa Masumi Beppu |
| |
Institution: | Laboratory of Engineering and Chemistry of Products, School of Chemical Engineering, University of Campinas, UNICAMP, Campinas 13083-852, Brazil. |
| |
Abstract: | A microstructured composite material made of collagen hydrogel (matrix) and silk fibroin microfibers (randomly oriented reinforcing fibers) is investigated in order to conjugate the mechanical resistance of fibroin with the suitable biological performance of collagen to design new scaffolds for vascular tissue engineering. Results show that fibroin microfibers and collagen fibrils have suitable interfacial adhesion, and the scaffold exhibits improved mechanical properties if compared with a pure collagen hydrogel. Furthermore, the overall biological performance is improved. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|