Protective effect of ginseng polysaccharides on influenza viral infection |
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Authors: | Yoo Dae-Goon Kim Min-Chul Park Min-Kyung Park Kyoung-Mi Quan Fu-Shi Song Jae-Min Wee Jae Joon Wang Bao-Zhong Cho Young-Keol Compans Richard W Kang Sang-Moo |
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Affiliation: | Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America. |
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Abstract: | Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection. |
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