Mutation accumulation in a selfing population: consequences of different mutation rates between selfers and outcrossers |
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Authors: | Nakayama Shin-ichiro Shi Shoi Tateno Masaki Shimada Masakazu Takahasi K Ryo |
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Affiliation: | Nikko Botanical Gardens, Graduate School of Science, The University of Tokyo, Tokyo, Japan. shin.ichiro.nak@gmail.com |
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Abstract: | Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious mutation rate between selfers and outcrossers. By analyzing the evolutionary stability of selfing and outcrossing in an infinite population, we found that the genome-wide deleterious mutation rate would be lower in selfing than in outcrossing organisms. When this difference in mutation rate was included in simulations, we found that in a small population, mutations accumulated more slowly under selfing rather than outcrossing. This result suggests that under frequent and intense bottlenecks, a selfing population may have a lower risk of genetic extinction than an outcrossing population. |
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