Microbial metabolism of quinoline and related compounds. III. Degradation of 3-chloroquinoline-8-carboxylic acid by Pseudomonas spec. EK III

Bacteria have been isolated with the ability to use 3-chloroquinoline-8-carboxylic acid as sole source of carbon and energy. According to their physiological properties, these bacteria have been classified as Pseudomonas spec. Two metabolites of the degradation pathway have been isolated and identified. The first metabolite was 3-(3-carboxy-3-oxopropenyl)-2-hydroxy-5-chloropyridine, the meta-cleavage product of 3-chloro-7,8-dihydroxyquinoline. The second metabolite, 5-chloro-2-hydroxynicotinic acid, was not further metabolized by this organisms.