Influence of selenium deficiency on vital functions in rats |
| |
Authors: | Akihiko Matsuda Mieko Kimura Yoshinori Itokawa |
| |
Institution: | (1) Department of International Health, Graduate School of Medicine, Kyoto University, 606-01 Kyoto, Japan;(2) Department of Social and Preventive Medicine, Graduate School of Medicine, Kyoto University, 606-01 Kyoto, Japan;(3) Infusion Research Department, Medical Information Development Division, Hoechst Marion Roussel Ltd., 1658, Ohshinohara, Yasucho, Yasugun, 520-23 Shiga, Japan |
| |
Abstract: | To clarify the relationship between selenium (Se) deficiency and functional disorders, the authors determined the Se concentration,
anti-oxidant enzyme activity, and other parameters in rats fed a Se-deficient diet. Rats fed the Se-deficient diet showed
a decrease in Se concentration and glutathione peroxidase (GSH-Px) activity in plasma, erythrocytes, heart, liver, and skeletal
muscle from the first week after the initiation of the diet, an increase in heart lipid peroxide concentration from the second
week, and an increase in liver glutathione S-transferase activity from the fourth week. From the twelfth week, a decrease
in the growth rate in the rats fed the Se-deficient diet was observed. In spite of this growth impairment, no changes in electrocardiogram,
muscle tone, degree of hemolysis, plasma biochemistry, or hematological values were detected. In summary, the authors found
that a reduction of body Se is easily induced, but that the appearance of functional disorders following Se deficiency is
difficult to detect in rats. |
| |
Keywords: | Selenium deficiency antioxidant system vital function |
本文献已被 SpringerLink 等数据库收录! |
|