Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. |
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| Authors: | A D Khanolkar D Lu P Fan X Tian A Makriyannis |
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| Institution: | Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269, USA. |
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| Abstract: | Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors. |
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