Inhibition of rat liver glutathione S-transferase isoenzymes by acrolein |
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| Authors: | T R Scott R E Kirsch |
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| Affiliation: | Department of Medicine, University of Cape Town, Medical School, Observatory, South Africa. |
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| Abstract: | The in vitro effect of the toxin and teratogen, acrolein, on the fetal rat liver glutathione S-transferase isoenzyme, YcYfetus, was investigated and compared with acrolein's effect on some of the adult rat liver glutathione S-transferase isoenzymes. Acrolein was found to inhibit all the isoenzymes investigated and double-reciprocal plots suggest that inhibition is either noncompetitive or mixed-type noncompetitive. It is therefore attractive to suggest that should a similar situation arise in vivo, it may provide one mechanism for the teratogenicity of acrolein. |
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