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Downhill protein folding: evolution meets physics |
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| Authors: | Gruebele Martin |
| Affiliation: | Department of Chemistry, University of Illinois, Urbana, IL 61801, USA. gruebele@scs.uiuc.edu |
| Abstract: | Proteins can be redesigned to fold downhill on a free energy surface characterized by only a few coordinates, confirming a principal prediction of the 'energy-landscape' model. Nonetheless, natural proteins have small but significant barriers. Spectroscopy and kinetics reveal potential biological causes for activation barriers during protein folding: evolution against protein aggregation and for protein function. |
| Keywords: | Protein function Temperature jump Hydrophobicity Activation barrier Fonction de la protéine Saut de température Hydrophobicité Barrière d'activation |
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