Synthesis and structure--activity relationship of novel aminotetralin derivatives with high micro selective opioid affinity |
| |
| Authors: | Roy Caroline Li Ticheao Krasik Pavel Gilbert Marie-Joseé Pelletier Christine Gagnon Diane Robert Ed Ducharme Julie Storer Richard Lavallée Jean-François |
| |
| Institution: | Shire Biochem, 275 Armand-Frappier Blvd., Laval, H7V 4A7, Québec, Canada. croy@ca.shire.com |
| |
| Abstract: | Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their micro-opioid receptor binding affinity. Selectivity index towards other opioid receptors and antinociceptive activity in mice have been evaluated for the most potent derivatives. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
