Tracing the evolutionary origin of the TFF-domain, an ancient motif at mucous surfaces. |
| |
| Authors: | P Sommer N Blin P G?tt |
| |
| Affiliation: | Division of Molecular Genetics, Department of Anthropology and Human Genetics, University of Tübingen, Wilhelmstr. 27, 72074, Tübingen, Germany. psmsommer@hotmail.com |
| |
| Abstract: | Mammalian trefoil factor family (TFF)-domain peptides promote gastrointestinal protection, healing and cell migration and may act as tumour suppressors. TFF-like domains also constitute modules of composite proteins like mucin glycoproteins and zona pellucida proteins. Database searches with a modified, less stringent consensus sequence - C-x(5,6)-[ST]-x(3)-C-x(4,5)-C-C-[FYWH]-x(2, 24)-C-[FY] - revealed that ancestors of the TFF-domain arose before amphibian evolution. Eggshell proteins and a zona pellucida-like protein in teleost species, an epidermis-specific protein in a tunicate as well as an open reading frame in a nematode exhibited TFF-like motifs suggesting that they most likely originated in some multicellular organism. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
