Design, synthesis and characterization of panning agents for the selection of metalloantibodies |
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| Authors: | Oliver Brü mmer, Changshou Gao, Shenlan Mao, David P. Weiner Kim D. Janda |
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| Affiliation: | (1) Department of Chemistry, The Scripps Research Institute, USA;(2) The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA, 92037, U.S.A |
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| Abstract: | The design, synthesis and characterization of a new class of metal complexes (panning agents) for the selection of antibodies from a combinatorial library are described. The metal panning agents contain a phosphorodithioate moiety that binds soft metals, leaving them coordinatively unsaturated. Subsequent panning against an antibody phage library selects for members that recognize, and bind directly to, the metal rather than ligands attached to the metal. |
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| Keywords: | mercury metalloantibodies metal panning agents metals phosphorodithioates |
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