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Genetic evidence for posterior specification by convergent extension in the Xenopus embryo
Authors:Tuneo Yamada  Sohan P Modak
Institution:Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland.;Molecular Embryology Research Laboratory, Department of Zoology, University of Pune, Pune 411 007, India.
Abstract:Genetic studies substantiate that mesodermal convergent extension expressed behind the anteroposterior borderline, in the form of a gradient with the posterior apex after gastrulation, regulates morphogenesis of the posterior zone at the dorsal and dorso-lateral levels which is in full agreement with the model of dorsalization–caudalization. In contrast, how anteroposterior specification of mesodermal tissues occurs at the ventral and latero-ventral levels is not yet understood.
Keywords:convergent extension  CSKA-eFGF  Xnot-2  differentiation of posterior axial tissues  dominant negative BMPR  dominant negative FGFR  MAP kinase activation  Xbra EnR  
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