Genetic evidence for posterior specification by convergent extension in the Xenopus embryo |
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| Authors: | Tuneo Yamada Sohan P Modak |
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| Institution: | Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland.;Molecular Embryology Research Laboratory, Department of Zoology, University of Pune, Pune 411 007, India. |
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| Abstract: | Genetic studies substantiate that mesodermal convergent extension expressed behind the anteroposterior borderline, in the form of a gradient with the posterior apex after gastrulation, regulates morphogenesis of the posterior zone at the dorsal and dorso-lateral levels which is in full agreement with the model of dorsalization–caudalization. In contrast, how anteroposterior specification of mesodermal tissues occurs at the ventral and latero-ventral levels is not yet understood. |
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| Keywords: | convergent extension CSKA-eFGF Xnot-2 differentiation of posterior axial tissues dominant negative BMPR dominant negative FGFR MAP kinase activation Xbra EnR |
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