Molecular genotypes of the human T cell receptor gamma-chain |
| |
| Authors: | Y Li P Szabo D N Posnett |
| |
| Affiliation: | Department of Medicine, Cornell University Medical College, New York, NY 10021. |
| |
| Abstract: | New RFLP of the human TCR gamma-chain defined by a single restriction enzyme (PvuII) are described. They define three alleles and allow haplotype assignments within families. They occur at a high frequency within the population studied and are useful for studies on disease associations with the gamma-chain genes. The PvuII sites flank the C gamma 2 gene. A polymorphic site maps to an area 0.5 kb downstream of C gamma 2-exon III. The second RFLP appears to be the result of a 3-kb insertion giving rise to differences in the number of copies of exon II in the C gamma 2 gene. |
| |
| Keywords: | |
|
|
