The BSA-induced Ca(2+) influx during sperm capacitation is CATSPER channel-dependent |
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| Authors: | Jingsheng Xia and Dejian Ren |
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| Institution: | (1) Depa rtment of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA |
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| Abstract: | Background Serum albumin is a key component in mammalian sperm capacitation, a functional maturation process by which sperm become competent
to fertilize oocytes. Capacitation is accompanied by several cellular and molecular changes including an increased tyrosine
phosphorylation of sperm proteins and a development of hyperactivated sperm motility. Both of these processes require extracellular
calcium, but how calcium enters sperm during capacitation is not well understood. |
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