Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa |
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Authors: | Gowhar Shafi Anjana Munshi Tarique N Hasan Ali A Alshatwi A Jyothy David KY Lei |
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Affiliation: | (1) Molecular Cancer Biology Lab, Department of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia;(2) Department of Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Hyderabad, India;(3) Department of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA |
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Abstract: | Background Cancer remains one of the most dreaded diseases causing an astonishingly high death rate, second only to cardiac arrest. The fact that conventional and newly emerging treatment procedures like chemotherapy, catalytic therapy, photodynamic therapy and radiotherapy have not succeeded in reverting the outcome of the disease to any drastic extent, has made researchers investigate alternative treatment options. The extensive repertoire of traditional medicinal knowledge systems from various parts of the world are being re-investigated for their healing properties. This study progresses in the direction of identifying component(s) from Nigella sativa with anti cancer acitivity. In the present study we investigated the efficacy of Organic extracts of Nigella sativa seed powder for its clonogenic inhibition and induction of apoptosis in HeLa cancer cell. |
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