Epidemiological and structural studies of Staphylococcus aureus R plasmids mediating resistance to tobramycin and streptogramin |
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| Authors: | N El Solh JM Fouace Z Shalita DH Bouanchaud RP Novick YA Chabbert |
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| Institution: | 1. Unité de Bactériologie Médicale, Institut Pasteur, 75724 Paris Cedex 15, France;2. The Public Health Research Institute of the City of New York, Inc., New York, New York 10016 USA |
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| Abstract: | We have studied the genetic properties of five S. aureus strains (serotypes 18 and III) isolated in France during a recent outbreak and carrying two new resistance characters (tobramycin and streptogramin). After transfer by transduction of these resistances, recipient cells were found in each case to harbor a single multicopy plasmid carrying the two resistance characters plus resistance to cadmium salts and/or resistance to tetracycline. The five Sgr-Tmr plasmids recovered by transduction are related epidemiologically; all five belong to the same incompatibility group and they share from 50 to 100% base sequence homology. Three of the five have similar restriction endonuclease patterns. |
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