TRP channels in Drosophila photoreceptors: the lipid connection |
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Authors: | Roger C. Hardie |
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Affiliation: | Department of Anatomy, Cambridge University, Downing Street, Cambridge CB2 3DY, UK |
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Abstract: | The light-sensitive current in Drosophila photoreceptors is mediated by transient receptor potential (TRP) channels, at least two members of which (TRP and TRPL) are activated downstream of phospholipase C (PLC) in response to light. Recent evidence is reviewed suggesting that Drosophila TRP channels are activated by one or more lipid products of PLC activity: namely diacylglycerol (DAG), its metabolites (polyunsaturated fatty acids) or the reduction in phosphatidylinositol 4,5-bisphosphate (PIP2). The most compelling evidence for this view comes from analysis of rdgA mutants which are unable to effectively metabolise DAG due to a defect in DAG kinase. The rdgA mutation leads to constitutive activation of both TRP and TRPL channels and dramatically increases sensitivity to light in hypomorphic mutations of PLC and G protein. |
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Keywords: | Calcium influx PIP2 Inositol lipids Phototransduction Diacylglycerol Arachidonic acid Phospholipase C rdgA PUFAs |
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