Disseminated <Emphasis Type="Italic">Penicillium Marneffei</Emphasis> Infection in an SLE Patient: A Case Report and Literature Review |
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Authors: | Di-Qing Luo Ming-Chun Chen Jun-Hua Liu Zhi Li Hui-Ting Li |
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Institution: | (1) Department of Dermatology, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-sen University, 183#, Huangpu Road E., 510700 Guangzhou, China;(2) Department of Dermatology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;(3) Department of Pathology, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;(4) Department of Laboratory, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China |
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Abstract: | Penicillium marneffei is an important opportunistic pathogen in Southeast Asia in HIV-positive individuals, but it rarely infects non-HIV ones.
Four SLE patients with disseminated penicilliosis had been previously reported out of which 3 died. We describe a 46-year-old
Chinese woman who had a 10 years history of SLE, associated with disseminated Penicillium marneffei infection, which presented as fever, subcutaneous masses, and fine nodular shadows disseminated over lung fields. She was
initially misdiagnosed as miliary tuberculosis and panniculitis that did not respond to anti-tubercular drugs and prednisone.
The correct diagnosis was finally made by histopathology and tissue culture and also culture from exudate. She responded well
to antifungal therapy in the form of intravenous amphotericin B for 2 weeks followed by itraconazole plus fluconazole. The
cutaneous lesions were cured leaving behind scars by secondary suture after times of epluchage, and the fine nodular shadows
over lungs disappeared finally. She had no recurrence on 8 months of follow-up. We also review the literature on this topic. |
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