The emerging role of adipokines in osteoarthritis: a narrative review |
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Authors: | Peng-fei Hu Jia-peng Bao Li-dong Wu |
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Institution: | (1) Zhejiang University College of Medicine, Hangzhou, People’s Republic of China;(2) Department of Orthopedics Surgery, The Second Hospital of Medical College, Zhejiang University, Jiefang Road 88#, 310009 Hangzhou, People’s Republic of China; |
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Abstract: | Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely
the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous
injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes
have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played
proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current
data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression
of OA. |
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Keywords: | |
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