Emergence of multi-drug-resistant Mycobacterium tuberculosis in Niger: A snapshot based on whole-genome sequencing |
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| Authors: | Zelika Harouna Hamidou Madjid Morsli Saidou Mamadou Michel Drancourt Jamal Saad |
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| Institution: | 1. Aix-Marseille-Univ, IRD, MEPHI, IHU Méditerranée Infection, Marseille, France;2. IHU Méditerranée Infection, Marseille, France;3. Laboratoire National de Référence des IST/VIH et de la Tuberculose, Niamey, Niger;4. Université Abdou Moumouni, Niamey, Niger; NIH-National Institute for Research in Tuberculosis-ICER, INDIA |
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| Abstract: | BackgroundAmong other West African countries experiencing the high endemicity of deadly tuberculosis, the situation in Niger is poorly evidenced by microbiological investigations.Methodology/Principal findingsThe study of 42 isolates of Mycobacterium tuberculosis from Niger by whole genome sequencing using Illumina iSeq technology yielded four M. tuberculosis lineages: Indo-Oceanic L1 (n = 1) (2.3%), East-Asian (n = 1) (2.3%), East-African Indian L3 (n = 2) (4.7%) and Euro-American L4 (n = 38) (90.4%). The sub-lineage L4.1.3 comprising 18 isolates (47.3%) was predominant, followed by the L4.6.2.2 sub-lineage (Cameroon genotype, n = 13 isolates) (34.2%). Investigating drug resistance profile for 12 antibiotics found 8/42 (19%) pan-susceptible isolates and 34/42 (81%) resistant isolates; with 40/42 (95.2%) isolates being susceptible to clofazimine-bedaquiline.Conclusions/SignificanceThese unprecedented data from Niger highlight the dynamics of tuberculosis transmission and drug resistance in Niger and may assist tuberculosis control in this country which continues to support a high burden of tuberculosis. |
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