Cooperation and virulence in acute Pseudomonas aeruginosa infections |
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| Authors: | Freya Harrison Lucy E Browning Michiel Vos Angus Buckling |
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| Affiliation: | (1) Department of Zoology, University of Oxford, South Parks Road, OX1 3PS Oxford, UK;(2) Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ Cambridge, UK;(3) Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tuebingen, Germany |
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| Abstract: | Background Efficient host exploitation by parasites is frequently likely to depend on cooperative behaviour. Under these conditions, mixed-strain infections are predicted to show lower virulence (host mortality) than are single-clone infections, due to competition favouring non-contributing social 'cheats' whose presence will reduce within-host growth. We tested this hypothesis using the cooperative production of iron-scavenging siderophores by the pathogenic bacterium Pseudomonas aeruginosa in an insect host. |
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