Evaluation of the activity of CYP2C19 in Gujrati and Marwadi subjects living in Mumbai (Bombay) |
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Authors: | Tanmay S Panchabhai Shaun F Noronha Sanish Davis Vishal M Shinde Nilima A Kshirsagar Nithya J Gogtay |
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Institution: | (1) Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, 400012, India |
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Abstract: | Background Inherited differences in the metabolism and disposition of drugs, and genetic polymorphisms in the targets of drug therapy
(e.g., receptors), can greatly influence efficacy and toxicity of medications. Marked interethnic differences in CYP2C19 (a
member of the cytochrome P-450 enzyme superfamily catalyzing phase I drug metabolism) which affects the metabolism of a number
of clinically important drugs have been documented. The present study evaluated the activity of CYP2C19 in normal, healthy
Gujrati and Marwadi subjects by phenotyping (a western Indian population). |
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