Stability of 70S ribosomes in relation to misreading and antibacterial activity of aminoglycosides. |
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Authors: | M A Cousin D Lando T Ojasoo J P Raynaud |
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Affiliation: | Centre de Recherches Roussel-Uclaf, 93230 Romainville, France |
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Abstract: | The anomeric aminoglycosides, RU 21886 and RU 23468, which both have a 2-deoxystreptamine residue, stabilize 70S ribosomes to similar extents at low magnesium ion concentrations. Only RU 21886, however, has marked antibacterial and bactericidal activity and gives rise to a high level of misreading in cell-free protein synthesizing systems. It would thus appear that the ability to stabilize the association of the two ribosomal subunits does not necessarily lead to errors in translation. |
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Keywords: | To whom all correspondence should be addressed. |
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