G-Proteins mediate inhibition and activation of Ca2+-induced exocytosis from SLO-permeabilized peptidergic nerve endings期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

G-Proteins mediate inhibition and activation of Ca2+-induced exocytosis from SLO-permeabilized peptidergic nerve endings

Authors:	Gudrun Ahnert-Hilger Govindan Dayanithi Karsten Spicher Jean J. Nordmann

Affiliation:	(1) Department of Internal Medicine, Universitätsklinikum Steglitz, Free University of Berlin, Germany;(2) Center de Neurochimie, CNRS, Strasbourg, France;(3) Department of Pharmacology, Free University of Berlin, Germany

Abstract:	In SLO-permeabilized isolated nerve endings from the rat neurohypophysis, GTP, guanosine 5[y-thio]triphosphate (GTPyS) and guanosine 5(ßy-imido]triphosphate (GMPPNP) inhibit the Ca²⁺-evoked vasopressin release. Pretreatment with pertussis toxin enhances the inhibitory effects of both GTP-analogues. Omission of Mg²⁺ overcomes the effect of GMPPNP and reverses the inhibitory effect of GTP and GTPyS. In the absence of Mg²⁺, GTP and GTPyS now potentiate Ca²⁺-evoked secretion.

Keywords:	Neurosecretion Vasopressin Guanine nucleotides G-proteins
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