Analyses of zebrafish and Xenopus oocyte maturation reveal conserved and diverged features of translational regulation of maternal cyclin B1 mRNA |
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Authors: | Yan Zhang and Michael D Sheets |
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Institution: | (1) Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue Madison, Madison, Wisconsin 53706, USA |
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Abstract: | Background Vertebrate development relies on the regulated translation of stored maternal mRNAs, but how these regulatory mechanisms may
have evolved to control translational efficiency of individual mRNAs is poorly understood. We compared the translational regulation
and polyadenylation of the cyclin B1 mRNA during zebrafish and Xenopus oocyte maturation. Polyadenylation and translational activation of cyclin B1 mRNA is well characterized during Xenopus oocyte maturation. Specifically, Xenopus cyclin B1 mRNA is polyadenylated and translationally activated during oocyte maturation by proteins that recognize the conserved
AAUAAA hexanucleotide and U-rich Cytoplasmic Polyadenylation Elements (CPEs) within cyclin B1 mRNA's 3'UnTranslated Region (3'UTR). |
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