Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids |
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| Authors: | Shows T B Brown J A Eddy R L Byers M G Haley L L Cooper E S Goggin A P |
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| Institution: | (1) Biochemical Genetics Section, Roswell Park Memorial Institute, New York State Department of Health, 14263 Buffalo, New York, USA;(2) Department of Human Genetics, Medical College of Virginia, 23298 Richmond, Virginia, USA |
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| Abstract: | Summary A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits.Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.This work was supported by NIH grants GM 20454 and HD 05196. |
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