Molecular Mapping of the ROSY Locus in DROSOPHILA MELANOGASTER |
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| Authors: | Babette Coté Welcome Bender Daniel Curtis and Arthur Chovnick |
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| Institution: | Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115;Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06268 |
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| Abstract: | The DNA from the chromosomal region of the Drosophila rosy locus has been examined in 83 rosy mutant strains. Several spontaneous and radiation-induced alleles were associated with insertions and deletions, respectively. The lesions are clustered in a 4-kb region. Some of the alleles identified on the DNA map have been located on the genetic map by fine-structure recombination experiments. The genetic and molecular maps are collinear, and the alignment identifies the DNA location of the rosy control region. A rosy RNA of 4.5 kb has been identified; its 5' end lies in or near the control region. |
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